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KMID : 1134820090380010032
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 1 p.32 ~ p.38
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The Effects of Herbal Extract Mixture on Anti-Obesity
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Chin Hwi-Seung
Park Keum-Ju
Park Seung-Hee
Kim Jae-Ki
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Abstract
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In this study, we investigated the anti-obesity activity of the herbal extract mixture (HEM). The inhibitory effect of HEM on triglyceride accumulation of 3T3-L1 preadipocyte was examined by Oil-Red O staining. HEM inhibited the triglyceride accumulation of 3T3-L1 preadipocyte cell and reduced glycerol-3-phosphate dehydrogenase (GPDH) activity. We further investigated the effect of HEM in prevention of obesity in male ICR mouse for 5 weeks. Experimental groups were divided into high fat diet group (HFD), HFD supplemented with 100 mg/kg HEM group (HEM1) and HFD supplemented with 200 mg/kg HEM group (HEM2). Body weight and food efficiency ration of HEM1 and HEM2 was decreased by 52% and 50% and by 45% and 50%, respectively. The amount of adipocyte in body weight was decreased. Blood triglyceride and total cholesterol of HEM1 was significantly decreased. These results indicate that HEM may be useful in preventing obesity.
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KEYWORD
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anti-obesity, 3T3-L1, GPDH, body weight, food efficiency ration
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